GLP-1 receptor agonists have expanded globally, leading to high demand and supply shortages. These medications are now on the FDA’s Drug Shortage List, prompting the FDA to issue guidance allowing compounding pharmacies to prepare alternatives while shortages persist.
Many patients and healthcare providers seek options beyond injections due to administration challenges, refrigeration requirements, and short shelf life per USP guidelines. Additionally, some individuals experience side effects such as nausea and headaches. These factors have led to the exploration of alternative formulations that offer a different approach.
How do GLP-1 receptor agonists work?
GLP-1 receptor agonists help regulate blood sugar by increasing insulin release in response to food, reducing glucose production by the liver, and slowing digestion. This process supports appetite control and can contribute to weight loss over time. These medications are designed to complement diet and exercise in managing blood sugar levels for adults with type 2 diabetes mellitus.
How do sublingual dosage forms work?
Oral administration presents challenges for these medications due to their high molecular weight, limited absorption from standard oral tablets, and sensitivity to heat during compounding. As specialists in customized medication, we prepare sublingual formulations designed for enhanced absorption.
Our sublingual suspension is made using both commercially available and bulk ingredients, along with a specialized anhydrous base. Our base is a self-emulsifying system specifically developed for high-molecular-weight drugs, providing mucoadhesive properties to prolong contact time. The medication is absorbed through the mucosal tissue under the tongue, with some absorption also occurring in the digestive system after swallowing.
How do I take sublingual medications?
The sublingual suspension is dispensed in a bottle with an oral syringe for precise dosing. To take it, draw the prescribed amount into the syringe, place the liquid under your tongue, and hold it for 60 seconds before swallowing any remaining medication. This once-daily regimen requires avoiding food, drinks, or other medications/supplements for at least 30 minutes before and after administration. The formulation remains stable for up to 90 days and does not require refrigeration or freezing.
Why choose Brighton Apothecary?
When selecting a compounding pharmacy, quality and reliability matter. Brighton Apothecary follows USP 795 guidelines, sources high-quality ingredients from FDA-registered facilities, and utilizes advanced technology to prepare medications tailored to your healthcare provider’s specifications. Our team ensures that each compounded prescription meets rigorous standards, giving you confidence in your personalized therapy.